Search on: VINCA ALKALOIDS 
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Descriptor English:   Vinca Alkaloids 
Descriptor Spanish:   Alcaloides de la Vinca 
Descriptor Portuguese:   Alcalóides de Vinca 
Tree Number:   D03.132.436.681.827
D03.438.473.402.681.827
Definition English:   A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS. 
Pharmacological Action:   Antineoplastic Agents
Tubulin Modulators
 
History Note English:   73 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
diagnostic use economics
history immunology
isolation & purification metabolism
pharmacology pharmacokinetics
poisoning radiation effects
supply & distribution standards
toxicity therapeutic use
urine  
Record Number:   15153 
Unique Identifier:   D014748 

Occurrence in VHL: 		 

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